The Price Virus. An Unclassified Enterovirus Isolated from Patients with Central Nervous System Disease.

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Abstract
Six immunologically related viral strains were recovered from the stools of patients with CNS disease. Neutralization tests indicate that they are not polioviruses, group A or group B Coxsackie viruses, ECHO virus types 1-28 or one of 4 ECHO candidate strains. The human origin of these agents is evidenced by the fact that 5 of the 6 patients with isolations showed 4-fold or greater rises in neutralizing antibody to these viruses. The several strains possess the characteristics of human enteroviruses, i.e., ether resistance, particle size, and production of a characteristic "enterovirus cytopathic effect" in monkey kidney cell cultures. All of the strains could be adapted to growth in HeLa cells. They are not pathogenic for suckling mice, and do not agglutinate human group O, chicken or guinea pig erythrocytes.