Heterogeneity of Sperm Density Profiles Following 20‐Week Therapy with High‐dose LHRH Analog Plus Testosterone

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Abstract
Eight normal male volunteers received an LHRH analog, 100 to 500?g daily, for 20 weeks. Testosterone enanthate, 100 mg, was given by injection every second week. Sperm density fell to 5.5 × 106/ml and to 0 in two of the subjects receiving 100?g, but was unchanged in the third. Three of the subjects who received 500?g displayed azoospermia, whereas the other two showed no significant change in sperm density. The reasons for the heterogeneity are not clear. Only one of the three nonresponders had testosterone values that were higher than the other subjects. Go-nadotropin levels were similar in responders and nonresponders. It is possible that the respone to LHRH analog in man is determined by the extent of the reduction in LH bioactivity.