Multistep Control of Pituitary Organogenesis
- 5 December 1997
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 278 (5344) , 1809-1812
- https://doi.org/10.1126/science.278.5344.1809
Abstract
Lhx3 and Lhx4 (Gsh4), two closely related LIM homeobox genes, determine formation of the pituitary gland in mice. Rathke's pouch is formed in two steps—first as a rudiment and later as a definitive pouch. Lhx3 and Lhx4have redundant control over formation of the definitive pouch.Lhx3 controls a subsequent step of pituitary fate commitment. Thereafter, Lhx3 and Lhx4 together regulate proliferation and differentiation of pituitary-specific cell lineages. Thus, Lhx3 and Lhx4 dictate pituitary organ identity by controlling developmental decisions at multiple stages of organogenesis.Keywords
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