GnRH agonist for triggering final oocyte maturation in patients at risk of ovarian hyperstimulation syndrome: still a controversy?
Open Access
- 7 February 2008
- journal article
- review article
- Published by Springer Nature in Journal of Assisted Reproduction and Genetics
- Vol. 25 (2-3) , 63-66
- https://doi.org/10.1007/s10815-008-9198-1
Abstract
An update on the subject of ovarian hyperstimulation syndrome (OHSS) prevention with GnRH agonist ovulation trigger. Review of pertinent English language studies published during the past 4 years. Randomized prospective studies support the notion that agonist trigger completely eliminates OHSS. Conflicting results regarding on going pregnancy rate probably reflect different approaches to luteal phase support. Embryos obtained and frozen after agonist trigger yield good clinical outcome in subsequent thaw cycles. The notion that agonist trigger can eliminate OHSS is strongly supported by randomized controlled trials. Further research is needed to assess optimal luteal support post agonist trigger.Keywords
This publication has 13 references indexed in Scilit:
- Triggering of final oocyte maturation with gonadotropin-releasing hormone agonist or human chorionic gonadotropin. Live birth after frozen-thawed embryo replacement cyclesFertility and Sterility, 2007
- The use of gonadotropin-releasing hormone (GnRH) agonist to induce oocyte maturation after cotreatment with GnRH antagonist in high-risk patients undergoing in vitro fertilization prevents the risk of ovarian hyperstimulation syndrome: a prospective randomized controlled studyFertility and Sterility, 2007
- Elective cryopreservation of all pronuclear oocytes after GnRH agonist triggering of final oocyte maturation in patients at risk of developing OHSS: a prospective, observational proof-of-concept studyHuman Reproduction, 2007
- Triggering ovulation with gonadotropin-releasing hormone agonists does not compromise embryo implantation ratesFertility and Sterility, 2006
- Serum inhibin A, VEGF and TNFα levels after triggering oocyte maturation with GnRH agonist compared with HCG in women with polycystic ovaries undergoing IVF treatment: a prospective randomized trialHuman Reproduction, 2006
- Incidence and prediction of ovarian hyperstimulation syndrome in women undergoing gonadotropin-releasing hormone antagonist in vitro fertilization cyclesFertility and Sterility, 2006
- GnRH agonist for triggering final oocyte maturation in the GnRH antagonist ovarian hyperstimulation protocol: a systematic review and meta-analysisHuman Reproduction Update, 2005
- A lower ongoing pregnancy rate can be expected when GnRH agonist is used for triggering final oocyte maturation instead of HCG in patients undergoing IVF with GnRH antagonistsHuman Reproduction, 2005
- GnRH agonist (buserelin) or hCG for ovulation induction in GnRH antagonist IVF/ICSI cycles: a prospective randomized studyHuman Reproduction, 2005
- Implantation: Clinical evidence for a detrimental effect on uterine receptivity of high serum oestradiol concentrations in high and normal responder patientsHuman Reproduction, 1995