EFFICACY AND SAFETY OF NABUMETONE IN LONG-TERM TREATMENT OF OSTEOARTHRITIS

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 6  (4) , 339-342
Abstract
Nabumetone, belonging to a new class of anti-inflammatory drugs, was administered to 9 patients suffering from radiologically-confirmed osteoarthritis of one or more of the following articulations: knees, hips, cervical and lumbar spine. A single nightly dose of 1 g was given for at least 1 yr, and up to 3 yr. The drug was generally effective on such criteria as articular mobility, night pain and pain during activity. No significant alterations which could be attributed to the treatment were seen in hematological parameters, blood creatinine and urea levels, protein, transaminases, alkaline phosphatse, .gamma.-glutamyl transferase and other blood and urine tests. The side-effects claimed by the patients included gastric upset, pyrosis, epigastric pain, constipation, malleolar edema and drowsiness. The complaints did not lead to termination of the treatment. The efficacy and safety of nabumetone found in this and other studies warrant its further investigation in the treatment of rheumatic diseases.