Effect of omeprazole and polyethylene glycol−400 on antipyrine elimination by the isolated perfused rat liver

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Abstract
The effect of the substituted benzimidazole, omeprazole, a potent inhibitor of gastric acid secretion, on the hepatic elimination of antipyrine was studied in the rat isolated perfused liver. Bolus dosage (10 mg in 100 ml perfusate) and infusions (1 μg ml−1 perfusate concentrations) of omeprazole in its solvent, polyethylene glycol−400 (PEG−400), reduced antipyrine clearance by approximately one third (P < 0·05). PEG−400 alone caused a 15% decrease in antipyrine clearance (P > 0·10), indicating that the effect seen with omeprazole was at least partly due to the vehicle of dissolution. A significant but mild choleresis was noted in all preparations (P < 0·01) exposed to PEG−400. We conclude that the effect of omeprazole on hepatic drug elimination in patients warrants further study.