Intracellular Localization of “Hematoporphyrin” in a Transplanted Tumor2
- 1 December 1961
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 27 (6) , 1369-1377
- https://doi.org/10.1093/jnci/27.6.1369
Abstract
The intracellular localization of porphyrin taken up by a transplanted rat tumor has been studied. Quantitative determination of the porphyrin concentrations in the subcellular fractions and direct observation by fluorescence microscopy indicate that porphyrin accumulates in the soluble fraction and not in the cell wall, nucleus, mitochondrial, or microsomal particles. There is suggestive evidence that selective uptake by the soluble fraction is due to a specific constituent to which the porphyrin is bound.Keywords
This publication has 8 references indexed in Scilit:
- The Use of a Derivative of Hematoporphyrin in Tumor Detection23JNCI Journal of the National Cancer Institute, 1961
- Presence and Distribution of Free Porphyrins in Transplants of a Chrysoidin-Induced Mouse Hepatoma2JNCI Journal of the National Cancer Institute, 1960
- QUANTITATIVE DETERMINATION OF PORPHYRIN UPTAKE BY TUMOR TISSUE FOLLOWING PARENTERAL ADMINISTRATION1960
- Attempts at tumor localization using CU64-labeled copper porphyrinsCancer, 1958
- LABELING OF HISTONES AND OTHER NUCLEAR PROTEINS WITH L-LYSINE-U-C14 IN TISSUES OF TUMOR-BEARING RATS1958
- Fluorescence of human lymphatic and cancer tissues following high doses of intravenous hematoporphyrinCancer, 1955
- DETERMINATION OF SERUM PROTEINS BY MEANS OF THE BIURET REACTIONJournal of Biological Chemistry, 1949
- INTRACELLULAR DISTRIBUTION OF ENZYMES .3. THE OXIDATION OF OCTANOIC ACID BY RAT LIVER FRACTIONS1948