EFFECT OF CARCINOGENS ON CHICKEN ATHEROSCLEROSIS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (7) , 2232-2235
Abstract
Weekly i.m. injections of the polycyclic hydrocarbon carcinogens, 7,12-dimethylbenz(a,h)anthracene (DMBA; 25 mg/kg per injection) and benzo(a)pyrene (50 mg/kg per injection) were given for a period of up to 22 wk to chickens (SC strain) beginning at age 4 wk. Atherosclerotic lesions of the abdominal aorta occurred more frequently and were larger in the DMBA- and benzo(a)pyrene treated birds than in controls. These lesions were proliferative in character as indicated by a higher [3H]thymidine autoradiographic labeling index compared to the underlying medial cells of the aorta. Measurements of serum cholesterol in DMBA-treated birds showed no difference from controls. Although both carcinogens accelerated the development of atherosclerotic plaques, DMBA was more potent than benzo(a)pyrene.

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