Characterization of a "heteroclitic" cytotoxic lymphocyte clone: heterogeneity of receptors or signals?
Open Access
- 1 February 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 130 (2) , 538-541
- https://doi.org/10.4049/jimmunol.130.2.538
Abstract
In this work we report the isolation of a cloned CTL that recognizes three genetically distinct specificities. Of interest is the fact that the hierarchy of the strength of these specificities is dependent on the functional assay used for their detection. This suggests that either the specificities are the result of interactions with independent receptors or the cell can modulate signals from cross-reactive antigens into different functional responses.This publication has 6 references indexed in Scilit:
- T cell clones with dual specificity for M1s and various major histocompatibility complex determinants.The Journal of Experimental Medicine, 1981
- MIs locus recognition by a cloned line of H-2-restricted influenza virus-specific cytotoxic T lymphocytes.The Journal of Immunology, 1981
- Simultaneous expression of H-2-restricted and alloreactive recognition by a cloned line of influenza virus-specific cytotoxic T lymphocytes.The Journal of Experimental Medicine, 1981
- Mechanisms of immune lysis. II. CTL-induced nuclear disintegration of the target begins within minutes of cell contact.The Journal of Immunology, 1980
- Clonal analysis of cytolytic T lymphocyte specificity. I. Phenotypically distinct sets of clones as the cellular basis of cross-reactivity to alloantigens.The Journal of Experimental Medicine, 1980
- Crossreactive mixed lymphocyte reaction determinants recognized by cloned alloreactive T cells.Proceedings of the National Academy of Sciences, 1979