THYROTROPHIN RELEASING HORMONE STIMULATES RELEASE OF [3H]‐DOPAMINE FROM SLICES OF RAT NUCLEUS ACCUMBENS in vitro
Open Access
- 1 November 1979
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 67 (3) , 323-325
- https://doi.org/10.1111/j.1476-5381.1979.tb08682.x
Abstract
Thyrotrophin releasing hormone (TRH) (25 to 100 μm) was found to stimulate the efflux of [3H]-dopamine from small slices of rat nucleus accumbens, but not from similar slices of rat caudate nucleus. Uptake inhibition was not responsible for this action, since at 10 and 50 μm TRH had no effect on the ability of small slices of nucleus accumbens to accumulate radioactivity when incubated with 10−7 m [3H]-dopamine. In addition the hormone had no effect on basal or dopamine-stimulated adenylate cyclase, nor did it displace [3H]-spiperone binding, in membrane preparations from nucleus accumbens.Keywords
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