Role of GABA in anxiety and depression
Top Cited Papers
- 20 November 2006
- journal article
- review article
- Published by Hindawi Limited in Depression and Anxiety
- Vol. 24 (7) , 495-517
- https://doi.org/10.1002/da.20262
Abstract
This review assesses the parallel data on the role of gamma‐aminobutyric acid (GABA) in depression and anxiety. We review historical and new data from both animal and human experimentation which have helped define the key role for this transmitter in both these mental pathologies. By exploring the overlap in these conditions in terms of GABAergic neurochemistry, neurogenetics, brain circuitry, and pharmacology, we develop a theory that the two conditions are intrinsically interrelated. The role of GABAergic agents in demonstrating this interrelationship and in pointing the way to future research is discussed. Depression Anxiety 24:495–517, 2007. PublishedKeywords
This publication has 308 references indexed in Scilit:
- Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming testNeuroscience & Biobehavioral Reviews, 2005
- Activation of the amygdala and anterior cingulate during nonconscious processing of sad versus happy facesNeuroImage, 2004
- The gamma amino butyric acid (GABA) receptor alpha‐3 subunit gene polymorphism in unipolar depressive disorder: A genetic association studyAmerican Journal Of Medical Genetics Part B-Neuropsychiatric Genetics, 2003
- Tiagabine for the Treatment of AnxietyDepression and Anxiety, 2003
- Anxiolytic-like effects of acute and chronic GABA transporter inhibition in ratsJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 2002
- Human GABAB receptor 1 gene: Eight novel sequence variantsHuman Mutation, 2001
- Role of GABA in memory and anxietyDepression and Anxiety, 1996
- Reduced benzodiazepine receptor binding in panic disorders measured by iomazenil SPECTJournal of Psychiatric Research, 1995
- Role of the amygdala and periaqueductal gray in anxiety and panicBehavioural Brain Research, 1993
- Direct evidence for mediation of an anticonflict effect of baclofen by GABAb receptorsPharmacology Biochemistry and Behavior, 1992