Induction of Antiphosphocholine Antibodies Utilizing Lambda Light Chains in BALB/c Mice
- 1 January 1987
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 83 (2) , 210-212
- https://doi.org/10.1159/000234358
Abstract
BALB/c mice immunized with 1 or 100 μg of phosphocholine (PC)-keyhole-limpet hemocyanin absorbed on aluminum hydroxide gel (alum) produced up to 50% λ1-light-chain-containing anti-PC antibodies in their serum. Only 10% λ1 antibodies were seen when complete Freund’s adjuvant or bentonite were used as the adjuvant or if PC-bovine serum albumin was used with alum. Thus, the induction of large A-antibody responses to PC (a response usually dominated by κ-antibodies) was both adjuvant- and carrier-dependent.Keywords
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