PROTECTION OF ISCHEMIC MYOCARDIUM - VOLUME-DURATION RELATIONSHIPS AND EFFICACY OF MYOCARDIAL INFUSATES

  • 1 January 1978
    • journal article
    • research article
    • Vol. 76  (5) , 698-705
Abstract
In studies in the isolated rat heart designed to optimize the composition of and infusion conditions for a cardioplegic, protective solution, a complex relationship between the duration and volume of infusion and the extent of tissue protection was observed. Solutions, which are based on extracellular electrolyte content, apparently afford (after a brief equilibration period) a constant degree of protection, irrespective of infusion volume or duration. Other solutions, e.g., the Bretschneider solution, have extremes of electrolyte concentration and are associated with a complex dose-response relationship. Infusion of small volumes for short durations affords an increasing degree of protection against ischemia. Increasing the infusate volume may result in a progressive loss of protection. Excessive infusion may lead to an exacerbation of ischemia-induced damage. The relative patterns and rates of re-equilibration of various ions, especially Na and Ca, during infusion may play a major role in determining the efficacy of the infusate.

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