Phenothiazine Derivatives and Brain Zinc

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Abstract
Normal topographic brain zinc localization and the influence of three phenothiazine tranquilizers (chlorpromazine, thioridazine, perphenazine) were studied in vitro and in vivo in eight brain regions of 80 mice and 80 rats, from one hour till 21 days after injection of 5 and 15 microcuries of zinc chloride Zn 65, respectively. Brains of untreated animals took up 0.11%, 0.24% (maximum), and 0.16% of dose per gram, one hour, 7 and 21 days, respectively, after injection. Each of the phenothiazine compounds increases the total brain zinc uptake in all animals, more in rats than in mice. Regional changes were detected in rat brains: the occipitoemporal cortex, thalamus, and hippocampus are more zincophilic, the thalamus especially under chlorpromazine and the hippocampus under perphenazine treatment.