CYCLOSPORINE AS AN ALTERNATIVE TO CYCLOPHOSPHAMIDE IN THE TREATMENT OF CHRONIC GRAFT-VERSUS-HOST DISEASE
- 1 February 1986
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 41 (2) , 170-172
- https://doi.org/10.1097/00007890-198602000-00007
Abstract
Four patients with progressive extensive chronic graft-versus-host disease or dose-limiting toxicity on conventional therapy (cyclophosphamide + prednisolone) were treated with a regimen of cyclosporine + prednisolone as induction therapy and cyclosporine as maintenance therapy. All 4 showed clinical improvement and 3 of 4 are alive at 9 months. The incidence of infections was not affected by this regimen, but steroid requirements were reduced.This publication has 7 references indexed in Scilit:
- Hepatic Graft Versus Host Disease: A Study of the Predictive Value of Liver Biopsy in DiagnosisHepatology, 1984
- Evidence for the presence of suppressor T lymphocytes in animals treated with cyclosporin A.The Journal of Immunology, 1982
- Effect of cyclosporin A on human lymphocyte responses in vitro. II. Induction of specific alloantigen unresponsiveness mediated by a nylon wool adherent suppressor cell.The Journal of Immunology, 1981
- Chronic graft-versus-host disease in 52 patients: adverse natural course and successful treatment with combination immunosuppressionBlood, 1981
- Chronic graft-versus-host syndrome in manThe American Journal of Medicine, 1980
- ANALYSIS OF LATE INFECTIONS IN 89 LONG-TERM SURVIVORS OF BONE-MARROW TRANSPLANTATION1979
- EFFECTS OF NEW ANTI-LYMPHOCYTIC PEPTIDE CYCLOSPORIN-A IN ANIMALS1977