Gamma Neuron Control by Thalamus and Globus Pallidus

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Abstract
Introduction In the search for the pathophysiological basis of rigidity in parkinsonism the suggestion has been made that abnormalities in the supranuclear control of the γ-motoneuron may be contributory. Since it has been demonstrated that a lesion in the globus pallidus may ameliorate rigidity and a lesion in the ventral nucleus of the thalamus may completely abolish it, efforts have been directed toward obtaining a better understanding of the anatomy and physiology of these structures. Hassler17 has postulated that a function of the substantia nigra might be supranuclear control of the γ-motoneurons. Destruction of the substantia nigra, seen frequently in parkinsonism with rigidity as the predominant sign, would then lead to insufficient excitation of the γ-motoneurons and in turn the muscle spindles. Thus, he believes rigidity is due, at least in part, to insufficient γmotoneuron excitation. In keeping with this theory, Stern and Ward39 have demonstrated inhibition

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