Cyclophilin‐A is a zinc‐dependent DNA binding protein in macrophages

Abstract
The association of cyclosporin A (CsA) immunosuppression with inhibition of transcription factor‐dependent lymphokine gene activation formed the basis of our decision to investigate nuclear‐associated Cyp isoforms. Immunofluorescence microscopy of mouse macrophages cell line with a monoclonal antibody mAb7F1 raised against CypA shows a co‐localisation of CypA in the nucleus and in the cytosol. Nuclear CypA binds to DNA in a zinc ion‐dependent manner, in contrast to recombinant CypB. Peptidyl‐prolyl cisltrans isomerase (PPIase) activity of nuclear CypA is inhibited by zinc ions. The zinc inhibited CypA does not bind cyclosporin A (CsA). We suggest that nuclear Cyp in complex with zinc ions recognizes DNA sequences and is involved in transcription modulating processes.