Der Zucker im Cerebrosid der Milz bei der Gaucher-Krankheit

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Abstract
The cerebroside was extracted from the spleen and liver ef a case of Gaucher''s disease as descr. previously (Hoppe-Seyler''s Zeitschr. physiol. Chem., 267: 128, 1940.) From 74 g. of dry spleen, 3.98 g. of cerebroside were obtained with an optical rotation of ([alpha])D20[degree]= -10.35[degree], while from 337 g. dry liver, 10.1 g. cerebroside were obtained with an optical rotation of [long dash]9.76[degree]. To detn. the nature of the sugar, the cerebrosides were heated with 20 vols. 10% aqueous HCl for 30 min. The mixtures were filtered, HCl removed from the filtrate with Pb acetate, etc., and the soln. concd. in vacuo. The sugar in the solns. was fermentable by yeast and was identified as glucose. The liver and spleen therefore contained a cerebroglucoside. In Gaucher''s disease, cerebro-glucosides are found more often in the liver and spleen than cerebrogalactosides.

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