THE EFFECTS OF VINCRISTINE ON PLATELET AGGREGATION STUDIED BY A FILTER LOOP TECHNIQUE IN THE RAT
Open Access
- 1 June 1980
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 69 (2) , 227-231
- https://doi.org/10.1111/j.1476-5381.1980.tb07894.x
Abstract
1 A method for measuring aggregation of platelets by adenosine diphosphate (ADP) is described using a filter inserted into the flowing aortic blood in the rat. 2 Repeated infusions of ADP resulted in a fall in the calculated aggregation index without significant changes in the platelet count. 3 Vincristine (0.05 mg/kg) intravenously caused significant inhibition of ADP-induced platelet aggregation. 4 Infusion of ADP caused some peripheral vasodilatation though it is unlikely that this contributed to the effects seen to any great extent.Keywords
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