Comparison of Biological Effects of Whole-Body Irradiation with 22.5-Mev X-Rays, 18-Mev Electrons, and 400-Kev X-Rays in the Rat

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Abstract
Comparison of several responses in the young rat (including LD50(3O), post-irradiation clinical behavior, cumulative percent mortality and body weight changes) revealed that there were no qualitative differences in the responses to single total body doses of high-energy irradiations (22.5 mev X-rays and 18 mev electrons) compared with responses to lower energy irradiations (400-kev X-rays). Definite quantitative differences in response to the high- and low-energy irradiations were noted, confirming observations by others. Because the 2 main mechanisms of death in these young rats were well-defined clinically and separated in time, young post-weanling rats are good subjects for comparison of effects of high-and low-energy irradiations.