α1-Adrenergic stimulation of Ca2+ mobilization without phosphorylase activation in hepatocytes from phosphorylase b kinase-deficient gsd/gsd rats
- 15 August 1981
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 198 (2) , 379-383
- https://doi.org/10.1042/bj1980379
Abstract
Phenylephrine, vasopressin and the bivalent cation ionophore A23187 mobilized Ca2+ normally, but failed to activate phosphorylase, in hepatocytes from gsd/gsd rats with a deficiency of liver phosphorylase b kinase. These data provide strong evidence that phosphorylase b kinase is the site of action of the Ca2+ mobilized intracellularly during .alpha.1-adrenergic activation of phosphorylase in liver cells.This publication has 24 references indexed in Scilit:
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