Reversal of diabetic retinopathy by continuous subcutaneous insulin infusion: a case report.

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Abstract
The case history of a 20 yr old diabetic girl with long-standing poorly controlled disease who presented with severe retinopathic features and who was treated with continuous subcutaneous insulin infusion (CSII) is reported. When first seen she had macular edema and a visual acuity of 6/18 in her only eye, together with multiple blot hemorrhages and intraretinal microvascular abnormalities. Marked reversal of the retinal lesions occurred within 65 days of initiating CSII and after only 36 days of constant normoglycemia. Subsequent good blood glucose control on conventional subcutaneous insulin injection was achieved, and the retinopathy remained quiescent with a visual acuity of 6/5. CSII may be a potentially useful method of arresting and reversing early diabetic retinopathy.