Decreased cellular permeability to H2O2 protects Saccharomyces cerevisiae cells in stationary phase against oxidative stress
- 16 November 2004
- journal article
- Published by Wiley in FEBS Letters
- Vol. 578 (1-2) , 152-156
- https://doi.org/10.1016/j.febslet.2004.10.090
Abstract
The higher resistance of stationary-phase Saccharomyces cerevisiae to H2O2 when compared with exponential phase is well characterized, but the molecular mechanisms underlying it remain mostly unknown. By applying the steady-state H2O2-delivery model, we show that (a) cellular permeability to H2O2 is five times lower in stationary--than in exponential phase; (b) cell survival to H2O2 correlates with H2O2 cellular gradients for a variety of cells; and, (c) cells in stationary phase are predicted to be more susceptible to intracellular H2O2 than in exponential phase. In conclusion, limiting H2O2 diffusion into cells is a key protective mechanism against extracellular H2O2.Keywords
This publication has 23 references indexed in Scilit:
- Decrease of H2O2 Plasma Membrane Permeability during Adaptation to H2O2 in Saccharomyces cerevisiaeJournal of Biological Chemistry, 2004
- Drug Susceptibilities of Yeast Cells Are Affected by Membrane Lipid CompositionAntimicrobial Agents and Chemotherapy, 2002
- Dynamics of cell wall structure inSaccharomyces cerevisiaeFEMS Microbiology Reviews, 2002
- Glucose-sensing and -signalling mechanisms in yeastFEMS Yeast Research, 2002
- Mutagenicity of methyl methanesulfonate and cyclophosphamide in resting and growing Saccharomyces cerevisiae D7 cellsMutation Research Letters, 1992
- Cholesterol and the cell membraneBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1985
- ESR determination of membrane order parameter in yeast sterol mutantsBiochimica et Biophysica Acta (BBA) - Biomembranes, 1979
- The effects of “Cell age” upon the lethal effects of physical and chemical mutagens in the yeast, Saccharomyces cerevisiaeMolecular Genetics and Genomics, 1976
- Assay of Yeast Enzymes in situEuropean Journal of Biochemistry, 1973
- Activity of catalase in the red cellBiochimica et Biophysica Acta (BBA) - Enzymology and Biological Oxidation, 1965