Inhibitory Activity of Xanthone Derivatives Isolated from Some Guttiferaeous Plants against DNA Topoisomerases I and II.

1 January 1997

journal article
Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN

Vol. 45 (2) , 418-420
https://doi.org/10.1248/cpb.45.418

Abstract

A xanthone derivative, subelliptenone F, and the related compounds showed an intensive inhibitory effect against topoisomerases I and II in in vitro experiments. These xanthones are prospective lead compounds for anticancer drugs.

Keywords

ANTICANCER
ACTIVITY OF XANTHONE
GUTTIFERAEOUS
XANTHONE DERIVATIVES ISOLATED
TOPOISOMERASES
INHIBITORY
SUBELLIPTENONE

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