Antigen presentation by liposomes: Inhibition with antibodies
- 1 January 1986
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 16 (6) , 717-720
- https://doi.org/10.1002/eji.1830160622
Abstract
The involvement of both antigen and class II major histocompatibility complex (MHC) molecules in T cell activation by liposome‐bound antigens was investigated. We used a pigeon cytochrome c (PCC)‐specific Ek‐restricted T cell hybridoma that can be activated to produce interleukin 2 by liposomes carrying either PCC and Ek molecules, or a high concentration of PCC alone. We demonstrated that the MHC‐restricted response of this hybridoma to liposomes is specifically blocked by both anti‐MHC and anti‐PCC monoclonal antibodies, whereas unrestricted activation is only inhibited by PCC‐specific antibody.This publication has 17 references indexed in Scilit:
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