Brief Communication: In Vivo Cortisone Sensitivity of Nonspecific Antitumor Activity of Corynebacterium parvum-Activated Mouse Peritoneal Macrophages2
- 1 March 1975
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 54 (3) , 789-792
- https://doi.org/10.1093/jnci/54.3.789
Abstract
The nonspecific antitumor activity of Corynebacterium parvum-activated mouse peritoneal macrophages in vitro was inhibited by their prior treatment with cortisone acetate in vivo. Inhibition was marked (60%) 24 hours after cortisone injection and was still significant at 7 days, but antitumor activity was completely recovered by 9 days. This transient inhibition was sufficient to abolish the nonspecific protection afforded by C. parvum in an in vivo pretreatment model.Keywords
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