The Stability of Chick Embryo Yellow Fever Vaccine During Storage

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Abstract
Summary: The data presented show that the desiccated yellow fever vaccine studied had, at the end of the first year of storage at 0 C to 4 C, a logarithmic titer of 1.5 to 2.0 below that of the original pulp. There was only a slight further decline in potency during the following 5 years of storage. There is evidence that vaccine lots prepared under different conditions all undergo a similar initial fall in potency. If the titer of the pulp is low, this initial decrease in potency will be sufficient to render the vaccine unsatisfactory for general distribution after 2–3 years of storage at 0 C.