Subtype‐Specific Enhancement of NMDA Receptor Currents by Mutant Huntingtin
Open Access
- 1 May 1999
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 72 (5) , 1890-1898
- https://doi.org/10.1046/j.1471-4159.1999.0721890.x
Abstract
Evidence suggests that NMDA receptor‐mediated neurotoxicity plays a role in the selective neurodegeneration underlying Huntington's disease (HD). The gene mutation that causes HD encodes a...Keywords
This publication has 67 references indexed in Scilit:
- Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansionNature Genetics, 1997
- Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in BrainScience, 1997
- SAP102, a Novel Postsynaptic Protein That Interacts with NMDA Receptor Complexes In VivoNeuron, 1996
- Glutamate Receptor Ion Channel Properties Predict Vulnerability to Cytotoxicity in a Transfected Nonneuronal Cell LineMolecular and Cellular Neuroscience, 1996
- Determination of NMDA NR1 subunit copy number in recombinant NMDA receptorsProceedings Of The Royal Society B-Biological Sciences, 1995
- A huntingtin-associated protein enriched in brain with implications for pathologyNature, 1995
- Widespread expression of Huntington's disease gene (IT15) protein productNeuron, 1995
- Calcium-induced actin depolymerization reduces NMDA channel activityPublished by Elsevier ,1993
- High Probability Opening of NMDA Receptor Channels by L-GlutamateScience, 1992
- Abnormalities of Striatal Projection Neurons andN-Methyl-D-Aspartate Receptors in Presymptomatic Huntington's DiseaseNew England Journal of Medicine, 1990