Regulation of APP Expression, Biogenesis and Metabolism by Extracellular Matrix and Cytokinesa
- 1 January 1996
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 777 (1) , 74-76
- https://doi.org/10.1111/j.1749-6632.1996.tb34403.x
Abstract
We have identified and characterized the ligand binding properties of the Alzheimer's disease (AD) βA4 amyloid protein precursor (APP), mapped the APP ligand binding sites and analyzed the regulation of APP expression, biogenesis and metabolism by components of the extracellular matrix (ECM) and cytokines.Keywords
This publication has 17 references indexed in Scilit:
- Intracellular routing of human amyloid protein precursor: Axonal delivery followed by transport to the dendritesJournal of Neuroscience Research, 1995
- Extracellular Matrix Influences the Biogenesis of Amyloid Precursor Protein in Microglial CellsJournal of Biological Chemistry, 1995
- APP gene family: unique age-associated changes in splicing of Alzheimer's βA4-amyloid protein precursorNeurobiology of Disease, 1994
- Interaction between the zinc(II) and the heparin binding site of the Alzheimer's disease βA4 amyloid precursor protein (APP)FEBS Letters, 1994
- The βA4 amyloid precursor protein binding to copperFEBS Letters, 1994
- Transforming growth factor β mediates increase of mature transmembrane amyloid precursor protein in microglial cellsFEBS Letters, 1994
- Identification and regulation of the high affinity binding site of the Alzheimer's disease amyloid protein precursor (APP) to glycosaminoglycansBiochimie, 1994
- Early and rapid de novo synthesis of Alzheimer βA4‐Amyloid precursor protein (APP) in activated microgliaGlia, 1993
- Amyloidogenicity of rodent and human βA4 sequencesFEBS Letters, 1993
- Specific binding of the alzheimer βA4 amyloid precursor to collagen, laminin, and heparinProtein Journal, 1992