A substrate analogue study on clavaminic acid synthase: possible clues to the biosynthetic origin of proclavamic acid
- 1 January 1993
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 6,p. 500-502
- https://doi.org/10.1039/c39930000500
Abstract
Incubation of (2S)-5-amino-(2′-oxoazetidin-1′-yl)pentanoic acid with clavaminic acid synthase gave (2S)-5-amino-2-(2′-oxoazetidin-1′-yl)pent-3,4-enoic acid as the major product, together with a small amount of proclayaminic acid; modification of the amino group to the guanyl group biased the mode of reactivity from desaturation to hydroxylation.Keywords
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