Inhibition of Dunning Tumor Growth by Melatonin

Publisher Website
Google Scholar
Abstract
Injections of the pineal hormone melatonin reduced growth and increased doubling time of the R3327H Dunning prostatic adenocarcinoma in the Copenhagen X Fisher rat. This occurred even though testosterone levels (50% of normal) were ostensibly high enough to maintain normal tumor growth. Melatonin may act directly upon the conversion of testosterone to dihydrotestosterone to inhibit tumor growth. Alternatively, a more complicated mechanism may be involved since studies on MCF breast cancer tissue indicate and estrogen requirement for inhibition of growth by melatonin.

This publication has 26 references indexed in Scilit: