Identification of 5,8-oxyretinoic acid isolated from small intestine of vitamin A-deficient rats dosed with retinoic acid.
- 1 June 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 75 (6) , 2603-2605
- https://doi.org/10.1073/pnas.75.6.2603
Abstract
A retinoid was isolated by a multistep procedure from the small intestines of vitamin A-deficient rats given a single dose of retinoic acid. The compound, designated 8II, was pure, as demonstrated by 4 high-pressure liquid chromatographic procedures. It was positively identified as 5,8-oxyretinoic acid by UV spectrophotometry, mass spectrometry and spectral and chromatographic comparison to known compounds. It is probable that 5,8-oxyretinoic acid was produced from 5,6-epoxyretinoic acid under the acidic conditions used in the isolation. It is highly probable that the natural product is 5,6-epoxyretinoic acid.Keywords
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