Prevalence of mutations in the BRCA1 gene among Chinese patients with breast cancer.
Open Access
- 19 May 1999
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 91 (10) , 882-885
- https://doi.org/10.1093/jnci/91.10.882
Abstract
Inherited mutations in the tumor susceptibility genes BRCA1 and BRCA2 account for about 70%-90% of familial breast cancer in most Caucasian populations while BRCA1 mutations alone contribute to about half of the cases (1-3). Epidemiologic data from Caucasians show that BRCA1 mutations occur in the general population at a frequency between 0.05% and 0.2%. BRCA1 mutations account for about 5% of all breast cancers and up to 12% of early-onset breast cancers (3,4). The relative contribution of BRCA2 may be slightly lower (2,3).Keywords
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