Replication of Herpes Simplex Virus in Human B Lymphocytes Stimulated by Epstein-Barr Virus

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Abstract
Human B lymphocytes prepared from adult blood or cord blood by the use of neuraminidase-treated sheep red blood cells which did not respond mitogenically to phyto-hemagglutinin or pokeweed mitogen, responded well to the B95–8 strain of Epstein-Barr virus, but not to the P3HR-1 strain, with increased incorporation of tritiated thymidine. Replication of herpes simplex virus could be demonstrated in cultures of B lymphocytes preincubated with the B95–8 strain.