Influence of Total Body X-irradiation on Tumor Induction by Parotid Tumor Agent in Adult Mice

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Abstract
Pleomorphic tumors of the parotid gland have been induced by PTA (polyoma virus) in non-immune adult C3Hf/BiLw mice given 300 r whole-body X-radiation. The latent period was long and few other primary sites were involved in tumor induction following intravenous injection of a virulent thymotrophic virus prepara-tion. Thymic epithelial tumors, induced in 100% of mice injected in the neonatal period, did not appear in mice injected as adults. Thymectomy therefore could not be shown to have an influence on the expression of tumors-in adult-injected mice. The response of X-rayed, adult C3Hf/BiLw mice receiving salivary gland explants exposed in vitro to PTA, was in contrast similar to the response of mice receiving virus within 24 hours post partum.

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