Acetylcholine receptor gene expression in experimental autoimmune myasthenia gravis
- 16 July 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 267 (2) , 231-235
- https://doi.org/10.1016/0014-5793(90)80932-9
Abstract
Acetylcholine receptor (AChR) gene expression was analyzed in experimental autoimmune myasthenia gravis (EAMG) in rabbits, rats and mice. An increase in AChR transcripts was demonstrated to be exclusively associated with myasthénie symptoms and with a severe loss in membrane AChR. An increase of α‐, β‐, ϵ‐, and δ‐subunit specific mRNAs (5.2‐, 1.6‐, 3.2‐ and 3.7‐fold, respectively), which code for the adult type of AChR (α2βϵδ) was observed in EAMG in rats. The γ‐subunit transcript was not detectable in myasthenie or healthy rats. It appears that the regulatory control of AChR gene expression in EAMG is different from that observed upon denervation.Keywords
This publication has 22 references indexed in Scilit:
- Developmental regulation of five subunit specific mRNAs encoding acetylcholine receptor subtypes in rat musclePublished by Wiley ,2001
- Increased levels of acetylcholine receptor α‐subunit mRNA in experimental autoimmune myasthenia gravisFEBS Letters, 1988
- Differential regulation of muscle acetylcholine receptor γ‐and ϵ‐subunit mRNAsFEBS Letters, 1987
- Molecular distinction between fetal and adult forms of muscle acetylcholine receptorNature, 1986
- Denervation supersensitivity in skeletal muscle: analysis with a cloned cDNA probe.The Journal of cell biology, 1984
- Acetylcholine-induced channels and transmitter release at human endplatesNature, 1978
- Immunological characterization of an irreversibly denatured acetylcholine receptorFEBS Letters, 1977
- Immunochemical studies on acetylcholine receptor from Torpedo californicaImmunochemistry, 1977
- Pathological mechanisms in experimental autoimmune myasthenia gravis. I. Immunogenicity of syngeneic muscle acetylcholine receptor and quantitative extraction of receptor and antibody-receptor complexes from muscles of rats with experimental automimmune myasthenia gravis.The Journal of Experimental Medicine, 1976
- Strain differences in the autoimmune response of mice to acetylcholine receptorsNature, 1976