Treatment of Bleeding in Hereditary Hemorrhagic Telangiectasia with Aminocaproic Acid

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Abstract
Hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber disease) is characterized by telangiectatic lesions of the nose, lips, and visceral organs including the liver, spleen, gastrointestinal tract, lungs, brain, and spinal cord1-5. It is inherited as an autosomal dominant trait. Its most common manifestations are recurrent epistaxis and gastrointestinal bleeding, which can be life threatening6. Nasal bleeding has been treated by dermatoplasty of the nasal septa, photocoagulation, and amniotic-membrane grafts6,7 and by the administration of estrogen and progesterone,8,9 but these treatments are often ineffective.