Quantitative Determination of Ethanolamine Phosphate and Free Amino Acids of Normal and Neoplastic Tissue

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Abstract
Summary 1. Quantitative measurements have been made by Dowex-50 chromatographic columns of the free amino acid content of the free cells of: rat thymi and testes, rabbit thymi, Ehrlich ascites carcinoma cells, mouse sarcoma cells, S-37 and S-180, Bagg reticulum cell sarcoma and Walker carcinoma. 2. The results indicate that taurine, ethanolamine phosphate, glycine and glutamic acid are the most abundant of the amino acids determined. 3. Proline, aspartic acid, serine and threonine occur in rather small quantity. 4. Alanine seemed to vary in quantity in the various cells. 5. The results were discussed in terms of the metabolic reactions which lead to the origin and fate of certain of these metabolites.