Presynaptic inhibition by neuropeptide Y of slow inhibitory synaptic transmission in submucous neurones of guinea‐pig caecum

Publisher Website
Google Scholar
Abstract
The occurrence and disposition of immunoreactivity for neuropeptide Y (NPY) was investigated in the submucosa of guinea‐pig caecum. There were few NPY‐immunoreactive neurones but intraganglionic varicose fibres were so numerous and strongly immunoreactive that some somata may have been obscured. In each neurone tested, exogenous application of NPY (1‐100 nM) depressed the duration and amplitude of the slow inhibitory postsynaptic potential. In contrast, NPY (1‐300 nM) had no effects on the resting membrane potential, input resistance and fast and slow excitatory synaptic transmission.

This publication has 0 references indexed in Scilit: