RENAL TUBULAR SITE OF ACTION OF FELODIPINE

  • 1 January 1984
    • journal article
    • research article
    • Vol. 228  (2) , 420-424
Abstract
The renal tubular site of action of felodipine was localized using renal clearance and recollection micropuncture techniques in the anesthetized rat. In initial renal clearance experiments, felodipine (2.75 nM/kg per min i.v. .times. 60 min) had no effect on mean arterial pressure or glomerular filtration but significantly increased urinary flow rate and Na and K excretion. In subsequent recollection micropuncture experiments, felodipine decreased mean arterial pressure but did not affect renal blood flow or renal vascular resistance or glomerular filtration rate; absolute and fractional urinary excretion of Na and water, but not K were increased. Proximal tubular and loop of Henle Na, K and water reabsorption were not affected but distal tubular and collecting duct Na and water (not K) reabsorption were decreased by felodipine. Felodipine is a vasodilator antihypertensive agent which, in doses which decrease mean arterial pressure in normotensive rats, increases urinary flow rate and Na excretion by inibiting distal tubular and collecting duct Na and water reabsorption; K reabsorption or excretion is not affected. As a vasodilator antihypertensive agent, felodipine possesses beneficial natriuretic rather than detrimental Na retaining properties.

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