Isolierung und Identifizierung eines serinhaltigen UDP-muramyl-tripeptides aus Butyribacterium rettgeri
Open Access
- 1 February 1968
- journal article
- Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung B
- Vol. 23 (2) , 217-220
- https://doi.org/10.1515/znb-1968-0216
Abstract
An UDP-activated murein precursor was isolated from Butyribacterium rettgeri after one hour inhibition by D-cycloserine. The compound contains UDP, muramic acid, L-serine, D-glutamic acid and L-ornithine in equimolar amounts. The amino acid sequence of the tripeptide attached to muramic acid is L-Ser-D-Glu-L-Orn as determined by end group analysis and identification of peptides obtained after partial hydrolysis. As shown by the identification of glutamic acid -γ-hydrazid after hydrazinolysis of the compound, ornithine is bound by its α-amino group to the γ-carboxyl group of glutamic acid. The amino acid sequence of the precursor is in agreement with the structure of the corresponding part of the whole murein of Butyribacterium rettgeri, as proposed recently.Keywords
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