The role of microtubule‐associated protein 2 (MAP‐2) in neuronal growth, plasticity, and degeneration

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Abstract
Microtubule associated protein 2 (MAP‐2) historically has been perceived primarily as a static, structural protein, necessary along with other cytoskeletal proteins to maintain neuroarchitecture but somewhat removed from the “mainstream” of neuronal response mechanisms. Quite to the contrary, MAP‐2 is exquisitely sensitive to many inputs and recent investigations have revealed dynamic functions for MAP‐2 in the growth, differentiation, and plasticity of neurons, with key roles in neuronal responses to growth factors, neurotransmitters, synaptic activity, and neurotoxins. These discoveries indicate that modification and rearrangement of MAP‐2 is an early obligatory step in many processes which modify neuronal function.

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