The Influence of Molecular Structure of Thiazine and Oxazine Dyes on Their Metachromatic Properties

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Abstract
In 29 thiazine and 12 oxazine dyes, greater metachromatic activity was found in thiazines than in their oxazine analogues. In the oxazine group only brilliant cresyl blue and the naphthophenoxazines showed marked metachromasia. Metachromasia was not shown by members of the thiazine series with the following N-substituents -NPr2; -NEt2; -NEtMe; -N(piperazino) and - N(morpholino). C-methyl substitution in positions 1 and 9 of the thiazine appeared to increase absorption in the beta peak relative to the alpha, even though the dye were nonmetachromatic; a peculiarity seen also in the naphthophenoxazines. Details of preparation, isolation and identification of the dyes are given.