Immune Recovery under Highly Active Antiretroviral Therapy Is Associated with Restoration of Lymphocyte Proliferation and Interferon‐γ Production in the Presence ofToxoplasma gondiiAntigens
Open Access
- 1 June 2001
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 183 (11) , 1586-1591
- https://doi.org/10.1086/320706
Abstract
The in vitro lymphocyte proliferative response (LPR) and interferon (IFN)–γ production in the presence of Toxoplasma antigen were evaluated in 97 human immunodeficiency virus (HIV)–1–infected patients with CD4 cell counts of 300 cells/μL but previously 300 cells/μL (group 3) and in 28 non–HIV-infected blood donors (group 4), all seropositive to Toxoplasma. In group 2, 81% of patients had a positive LPR, versus 20% in group 1 (P300 cells/μL (odds ratio [OR], 16.3; 95% confidence interval [CI], 5.3–50.2) and anti-Toxoplasma IgG titer >150 IU/mL (OR, 5; 95% CI, 1.6–15.2). Immune reconstitution under highly active antiretroviral therapy was associated with a restoration of immune responses against ToxoplasmaKeywords
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