The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization
- 1 January 1988
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 48 (1) , 6-8
- https://doi.org/10.1159/000132575
Abstract
The Na+/H+ antiporter is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells. We cloned the human gene capable of complementing antiporter-deficient mouse fibroblasts and isolated an exon-containing genomic DNA fragment. Using this genomic probe, we mapped the putative structural gene of the amiloride-sensitive Na+/H+ antiporter to the human chromosome region 1p35→p36.1 by in situ hybridization.Keywords
This publication has 2 references indexed in Scilit:
- Functional expression of a human Na+/H+ antiporter gene transfected into antiporter-deficient mouse L cells.Proceedings of the National Academy of Sciences, 1986
- DNA probe localization at 18p113 band by in situ hybridization and identification of a small supernumerary chromosomeHuman Genetics, 1985