Genetic Predisposition to Renal Stone Disease in the First-Degree Relatives of Stone-Formers

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Abstract
Stone formers, their spouses and 1st degree relatives were investigated for hypercalciuria and crystalluria. The incidence of hypercalciuria was far greater in stone-formers and their 1st degree relatives than in their spouses. The urine of the stone-formers and their 1st-degree relatives contained calcium oxalate crystals in greater number and of larger size than that of the spouses or the controls. Apparently, the predisposition to renal stone disease was far greater in those who shared the genetic pattern of stone-formers than those who shared their environmental conditions only.

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