Improvement in HIV-related endothelial dysfunction using the anti-inflammatory agent salsalate: a pilot study
- 12 March 2008
- journal article
- research article
- Published by Wolters Kluwer Health in AIDS
- Vol. 22 (5) , 653-655
- https://doi.org/10.1097/qad.0b013e3282f470d2
Abstract
We hypothesized that heightened systemic inflammation contributes to the increased rate of cardiovascular events in HIV-infected patients not receiving combination antiretroviral therapy. We performed a pilot trial to assess the effects of the nuclear factor-κB inhibitor salsalate on flow-mediated dilation of the brachial artery, a measure of endothelial function. Flow-mediated dilation significantly improved after 8 weeks of salsalate. However, hepatotoxicity occurred frequently. Research using alternative agents is warranted to examine the role of inflammation in HIV-related cardiovascular disease.Keywords
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