Reactions of Nitrones with Free Radicals. II. Formation of Nitroxides

Abstract
Reactions of N-t-butylaldonitrones with free radicals gave stable nitroxides, one of which was isolated in pure state. The stability of the nitroxides was explained by the steric effect around the nitrogen and α-carbon atoms. In the reaction of 5,5-dimethyl-Δ1-pyrroline N-oxide with AIBN, nitroxide was detected by ESR technique, and 1,3-adduct and ketonitrone were isolated from the reaction mixture. From the results, it was confirmed that nitroxide is the intermediate of the 1,3-adduct formation and that a radical first adds to the carbon atom and then adds to the oxygen atom of the nitrones.
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