Plasma esterase and acid ribonuclease following the injection of heparin in dogs

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Abstract
Heparin, 1.5-4.0 mg/kg, was injected intravenously into dogs. Increases were observed regularly in the activities of total- and eserine-resistant tributyrin esterase and of acid ribonuclease in the plasma. These occurred 2-15 min following the injection of heparin, remained elevated for 4-5 h, and returned to normal levels within 24 h. Eserine-sensltive esterase declined following the injection and no changes were observed in the activities of acid [beta]-glycerophosphatase, [beta]-glucuronidase, or cathepsin. The results are discussed in terms of the mechanisms of enzyme release following the injection of heparin.