Disintegrating Force and Tablet Properties

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Abstract
The development of a disintegrating force inside the tablet due to the liquid/solid contact depends on a proper wetting of the material and occur according to saturation kinetics. The aim of the present work is the evaluation of such a force development in relation to the characteristics of the tablet in particular to the compression force. For this purpose, the disintegrating force of different tablets formulations has been measured by means of a previously described apparatus. The results obtained show that a new evaluation of a compact disintegration characteristics may be obtained through the determination of such parameters as the maximum force developed (y0) and the time of the half maximum force development (b).